PSN-GK1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: PSN-GK1 | CAS No.: 745051-61-0 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | PSN-GK1 |
| Description | PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM). |
| In vivo | PSN-GK1 demonstrates an excellent pharmacokinetic profile with high oral bioavailability in rats and significantly reduces blood glucose levels, showing potent antihyperglycemic effects in diabetic rodents without causing hypoglycemia [1]. At 5 mM glucose, PSN-GK1 activates glucokinase (4.3-fold, EC50: 130 nM), increases MIN6 insulin secretion (26-fold, EC50: 267 nM), and enhances 2-DG hepatocytic uptake (3-fold, EC50: 1 μM). In C57Bl/6 mice, PSN-GK1 reduces blood glucose at 1 and 10 mg/kg orally, with significant insulin increase only at the higher dose. In hyperinsulinemic 10-mM glucose clamps, PSN-GK1 increases 2-DG incorporation into liver glycogen sixfold [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PSN-GK1 | PSNGK1 | PSN GK1 | PSN-GK-1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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