Radicicol NEW
| Price | $139 |
| Package | 1mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: Radicicol | CAS No.: 12772-57-5 |
| Supply Ability: 10g | Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | Radicicol |
| Description | Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel |
| In vitro | Radicicol inhibits PDK1 activity with an IC50 value of 230 mM and PDK3 with an IC50 value of 400 μM.[1] |
| In vivo | Methods: Radicicol (20 mg/kg/60 mg/kg, intraperitoneal injection, 2 doses, 1 h apart) was administered to mice to observe its inhibitory effect on (I/R) injury in mice. Results: Radicicol has a renal protective effect, improves renal ischemia-reperfusion (I/R) injury, and increases renal HSP70 mRNA and protein in mice with renal injury. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (219.31 mM), Sonication is recommended. |
| Keywords | Radicicol | HSP90 |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Ethyl linoleate | D-Psicose | Fenpyroximate | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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