SKLB-163 NEW
| Price | $137 | $336 | $497 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: SKLB-163 | CAS No.: 1255099-06-9 |
| Purity: 99.23% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | SKLB-163 |
| Description | SKLB-163 is a small-molecule inhibitor and a RhoGDI inhibitor with oral bioactivity, cell permeability, and selectivity. This compound induces tumor cell apoptosis, inhibits proliferation and migration, and enhances radiosensitivity by downregulating RhoGDI, activating the JNK-1/caspase-3 pathway, and suppressing Akt and p44/42 MAPK phosphorylation. |
| In vitro | Methods: Nasopharyngeal carcinoma (NPC) cells were treated with various concentrations (0–20 μM) of SKLB-163 for 48 h, and changes in cell proliferation, migration, and radiosensitivity were detected. Results: SKLB-163 inhibited proliferation and migration of nasopharyngeal carcinoma (NPC) cells and sensitized the cells to radiation. [1] Methods: A375, SPC-A1, SW620, HeLa, and PC-3 cells were treated with various concentrations (0–20 μM) of SKLB-163 for 48 h to detect cytotoxic effects. A375 cells were treated with various concentrations (0–2.5 μM) of SKLB-163 for 48 h to detect apoptosis and colony formation. Results: SKLB-163 showed cytotoxic effects in A375, SPC-A1, SW620, HeLa, and PC-3 cells, and could induce apoptosis and inhibit colony formation in A375 cells. [2] |
| In vivo | Methods: To detect in vivo antitumor and radiosensitizing effects, SKLB-163 (25–100 mg/kg, gavage, once daily for 30 days) was administered alone in a nasopharyngeal carcinoma mouse model, or combined with radiotherapy (3 Gy radiation once daily for 3 days starting on day 6 of SKLB-163 administration). Results: SKLB-163 alone inhibited tumor growth and ascites formation, and suppressed liver and lung metastasis; combined administration sensitized nasopharyngeal carcinoma tumors to radiation. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 247.5 mg/mL (609.73 mM), Sonication is recommended. |
| Keywords | SKLB-163 | SKLB 163 | RhoGDI | p44/42 MAPK | JNK1 | caspase-3 | Akt |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Ethyl linoleate | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Glutamine Metabolism Compound Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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