SX-517 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: SX-517 | CAS No.: 1240494-13-6 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | SX-517 |
| Description | SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca2? flux (IC?? = 38 nM), antagonises CXCL-8-induced [(3?)S]GTPγS binding (IC?? = 60 nM), and suppresses ERK1/2 phosphorylation. |
| In vitro | SX-517 (0.1 nM-0.1 mM; 60 minutes) inhibited 10 nM CXCL8-induced [35S]GTPγS binding with an IC50 of 60 nM [1]. SX-517 (10 μM; 60 minutes) suppressed the cell surface expression of CXCR2 receptors in HEK293 cells [1]. SX-517 (10 μM; 0-30 minutes) blocked CXCR2-mediated ERK1/2 phosphorylation in HEK293 cells [1]. |
| In vivo | SX-517 (0.02 mg/kg and 0.2 mg/kg) was administered via single intravenous injection to male CD1 SWISS mice bearing utetheisa ornatrix air pouches on their backs. The results demonstrated a significant reduction in cell counts within the utetheisa ornatrix air pouches of the mice [1]. |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (209.3 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (8.63 mM), Sonication is recommended. |
| Keywords | SX-517 |
| Inhibitors Related | AZD8309 | rac-NBI-74330 | Tannic acid | Artemotil | CXCR2-IN-1 | Kynurenic acid | Soquelitinib | Plerixafor octahydrochloride | Tanimilast | 3-Indoleglyoxylic acid | Nicotinamide N-oxide | CXCL-CXCR1/2-IN-1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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