SX-3228 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: SX-3228 | CAS No.: 156364-04-4 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | SX-3228 |
| Description | SX-3228 is a selective agonist of benzodiazepine1 (BZ1) receptor(IC50 of 17 nM). |
| In vitro | SX-3228 is a selective ligand for the BZ1 receptor, binding preferentially with an IC50 of 17 nM. It exhibits very weak affinity for the BZ2 receptor (spinal cord: IC50=127 nM) and negligible affinity for the peripheral type BZ receptor (kidney: IC50>10000 nM). SX-3228 does not bind to dopamine (D1, D2), serotonin (5-HT1, 5-HT2, 5-HT3), noradrenaline (α1, α2, β), GABA, or acetylcholine (muscarinic) subtypes. |
| In vivo | Administering SX-3228 at doses ranging from 0.5 to 2.5 mg/kg to rats during their active (light) phase significantly diminishes rapid-eye-movement sleep (REMS) (P<0.05), particularly in the third hour of observation. Conversely, introducing SX-3228 in the same dosage range at the onset of the inactive (dark) phase profoundly alters sleep architecture: it markedly reduces wakefulness (W) and enhances slow-wave sleep (SWS) throughout a 6-hour examination period in a dose-dependent manner (P<0.05-0.01). Notably, these significant effects in the final hour are exclusively observed at the highest administered dose of 2.5 mg/kg (P<0.01). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SX-3228 | SX3228 | SX 3228 | BZ1 receptor |
| Inhibitors Related | Valproic acid sodium salt | p-Hydroxybenzaldehyde | Urethane | Baicalin | Imidazoleacetic acid hydrochloride | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | (-)-α-Pinene | Nipecotic acid | Dihydromyricetin | Methionine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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