SX-3228 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: SX-3228 | CAS No.: 156364-04-4 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | SX-3228 |
| Description | SX-3228 is a selective agonist of benzodiazepine1 (BZ1) receptor(IC50 of 17 nM). |
| In vitro | SX-3228 is a selective ligand for the BZ1 receptor, binding preferentially with an IC50 of 17 nM. It exhibits very weak affinity for the BZ2 receptor (spinal cord: IC50=127 nM) and negligible affinity for the peripheral type BZ receptor (kidney: IC50>10000 nM). SX-3228 does not bind to dopamine (D1, D2), serotonin (5-HT1, 5-HT2, 5-HT3), noradrenaline (α1, α2, β), GABA, or acetylcholine (muscarinic) subtypes. |
| In vivo | Administering SX-3228 at doses ranging from 0.5 to 2.5 mg/kg to rats during their active (light) phase significantly diminishes rapid-eye-movement sleep (REMS) (P<0.05), particularly in the third hour of observation. Conversely, introducing SX-3228 in the same dosage range at the onset of the inactive (dark) phase profoundly alters sleep architecture: it markedly reduces wakefulness (W) and enhances slow-wave sleep (SWS) throughout a 6-hour examination period in a dose-dependent manner (P<0.05-0.01). Notably, these significant effects in the final hour are exclusively observed at the highest administered dose of 2.5 mg/kg (P<0.01). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SX-3228 | SX3228 | SX 3228 | BZ1 receptor |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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