Product Details
| Product Name:
tBID |
CAS No.:
1639895-85-4 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | tBID |
| Description | tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM) |
| In vitro | Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase that regulates cell proliferation and survival. TBID exhibits exceptional efficacy against HIPK2 with an IC50 of 0.33 μM and a Gini coefficient of 0.592 out of a panel of 76 kinases. Although TBID also inhibits HIPK1 and HIPK3, it is less effective against these kinases. TBID acts competitively with ATP, consistent with modeling, and interacts with the hinge region through hydrophobic interactions with Val 213, Val 261, Phe 277, Leu 280, Met 331, and Ile 345, while the symmetric nitrogen atom at position 3 engages with the catalytic Lys 228, playing a crucial role in binding architecture. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 26 mg/mL (49.17 mM), Sonication and heating are recommended.
|
| Keywords | tBID | HIPK2 |
| Inhibitors Related | ML 315 | EHT 1610 | ARN25068 | MBM-55S | CK2/ERK8-IN-1 | YK-2-69 | AnnH31 | GNF4877 | Harmine hydrochloride | 2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi | RD0392 | LDN-192960 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1698.00
|
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-10-28 |
United States