Product Details
| Product Name:
tBID |
CAS No.:
1639895-85-4 |
| Supply Ability:
10g |
Release date:
2025/10/28 |
Product Introduction
Bioactivity
| Name | tBID |
| Description | tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM) |
| In vitro | Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase that regulates cell proliferation and survival. TBID exhibits exceptional efficacy against HIPK2 with an IC50 of 0.33 μM and a Gini coefficient of 0.592 out of a panel of 76 kinases. Although TBID also inhibits HIPK1 and HIPK3, it is less effective against these kinases. TBID acts competitively with ATP, consistent with modeling, and interacts with the hinge region through hydrophobic interactions with Val 213, Val 261, Phe 277, Leu 280, Met 331, and Ile 345, while the symmetric nitrogen atom at position 3 engages with the catalytic Lys 228, playing a crucial role in binding architecture. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 26 mg/mL (49.17 mM), Sonication and heating are recommended.
|
| Keywords | tBID | HIPK2 |
| Inhibitors Related | T025 | Harmine | ML 315 | EHT 1610 | ARN25068 | MBM-55S | CK2/ERK8-IN-1 | YK-2-69 | AnnH31 | GNF4877 | Harmine hydrochloride | LDN-192960 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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