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Postion:Product Catalog >TH34
TH34
  • TH34

TH34 NEW

Price $38 $89 $128
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-25

Product Details

Product Name: TH34 CAS No.: 2196203-96-8
Purity: 98.77% Supply Ability: 10g
Release date: 2026/05/25

Product Introduction

Bioactivity

NameTH34
DescriptionTH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.
Cell ResearchHeLa cells, stably transfected with NanoBRET plasmids NanoLuc?-HDAC6 FL Fusion Vector and NanoLuc?-HDAC10 FL Fusion Vector were seeded at 20,000 cells/well in white 96-well plates. Without further incubation, tracer (0.3 μM) and drugs were added in separate steps and plates were placed in a tissue culture incubator for 2 h. For NanoBRET quantification, plates were put at room temperature for 10 min. Nanoglow substrate, diluted in OptiMEM without phenol red, was added and measured within 10 min in an OPTIMA plate reader (460 nm emission for donor and 610LP filter for acceptor). The BRET signal was calculated by the ratio of acceptor signal to donor signal.
In vitroTH34 is well-tolerated by non-transformed human skin fibroblasts at concentrations up to 25 μM and modestly impairs colony growth in medulloblastoma cell lines, but specifically induces caspase-dependent programmed cell death in a concentration-dependent manner in several human neuroblastoma cell lines.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationH2O : Insoluble
DMSO : 80 mg/mL (312.13 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (12.88 mM), Sonication is recommended.
KeywordsTH-34 | TH34 | TH 34 | Inhibitor | inhibit | Histone deacetylases | HDAC8 | HDAC6 | HDAC10 | HDAC
Inhibitors RelatedPanobinostat | Theophylline monohydrate | Valproic acid sodium salt | Methoxyacetic acid | Sodium 4-phenylbutyrate | Acefylline | Manganese chloride (tetrahydrate) | Curcumin | Valproic Acid | Sodium butanoate | 4-Phenylbutyric acid | Theophylline
Related Compound LibrariesHistone Modification Compound Library | DNA Damage & Repair Compound Library | Reprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Epigenetics Compound Library | Chromatin Modification Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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