Product Details
| Product Name:
Zopolrestat |
CAS No.:
110703-94-1 |
| Purity:
99.82% |
Supply Ability:
10g |
| Release date:
2026/07/14 |
Product Introduction
Bioactivity
| Name | Zopolrestat |
| Description | Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM). |
| In vitro | Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose[1]. |
| In vivo | After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 0.5 mg/mL (1.19 mM), Sonication is recommended.
DMSO : 11 mg/mL (26.23 mM), Sonication is recommended.
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| Keywords | Zopolrestat | rats | potent | oral | Inhibitor | inhibit | glyceraldehyde | glucose | diabetic | Aldose Reductase | aldose |
| Inhibitors Related | FH1 | Furaneol | Epalrestat | Quercitrin hydrate | Dicoumarol | 4-hydroxyphenyl acetate | Lapisteride | Alpha-Estradiol | Finasteride | Isoliquiritigenin | AKR1C1-IN-1 | Kopexil |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Diabetic Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Endocrinology-Hormone Compound Library | Orally Active Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States