Product Details
| Product Name:
Timegadine |
CAS No.:
71079-19-1 |
| Supply Ability:
10g |
Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | Timegadine |
| Description | Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets. |
| In vitro | Timegadine is a potent, competitive COX and lipo-oxygenase inhibitor, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets[2],and is a new antiinflammatory agent, |
| In vivo | Timegadine, a new anti-inflammatory agent, is a potent, competitive inhibitor of prostaglandin synthetase, additionally inhibiting cyclo-oxygenase (COX) and lipoxygenase. Administering Timegadine orally at doses ranging from 10 to 30 mg/kg daily effectively suppresses both the initial and subsequent lesions of adjuvant arthritis, particularly when treatment commences on the induction day and extends for 28 days. Notably, Timegadine can prevent the swelling of the non-injected paw for up to 28 days post-adjuvant injection, especially when administered five days before and after disease onset, mirroring the impact of cyclophosphamide[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Timegadine | SR-1368 | SR 1368 | lipo-oxygenase | COX |
| Inhibitors Related | Naproxen sodium | Acetaminophen | Phenidone | 4-Aminosalicylic acid | Gallic Acid Monohydrate | Diclofenac Potassium | Indomethacin | Paradol | Trometamol | 5-Methylfurfural | Phenylbutazone | Magnesium sulfate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1520.00
|
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-07-17 |
United States