Product Details
| Product Name:
Timegadine |
CAS No.:
71079-19-1 |
| Supply Ability:
10g |
Release date:
2025/07/17 |
Product Introduction
Bioactivity
| Name | Timegadine |
| Description | Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets. |
| In vitro | Timegadine is a potent, competitive COX and lipo-oxygenase inhibitor, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets[2],and is a new antiinflammatory agent, |
| In vivo | Timegadine, a new anti-inflammatory agent, is a potent, competitive inhibitor of prostaglandin synthetase, additionally inhibiting cyclo-oxygenase (COX) and lipoxygenase. Administering Timegadine orally at doses ranging from 10 to 30 mg/kg daily effectively suppresses both the initial and subsequent lesions of adjuvant arthritis, particularly when treatment commences on the induction day and extends for 28 days. Notably, Timegadine can prevent the swelling of the non-injected paw for up to 28 days post-adjuvant injection, especially when administered five days before and after disease onset, mirroring the impact of cyclophosphamide[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Timegadine | SR-1368 | SR 1368 | lipo-oxygenase | COX |
| Inhibitors Related | Bismuth Subsalicylate | Ibuprofen | Acetaminophen | Salicylamide | Diclofenac sodium | Diclofenac Potassium | trans-Cinnamaldehyde | Paradol | Indomethacin sodium hydrate | Salicylic acid | Glafenine | Revaprazan hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$1520.00
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VIP4Y
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TargetMol Chemicals Inc.
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2026-04-21 |
United States