Product Details
| Product Name:
Tiotidine |
CAS No.:
69014-14-8 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Tiotidine |
| Description | Tiotidine is a selective histamine H2-receptor antagonist (pA2=7.3-7.8 for guinea-pig right atrium). |
| In vitro | Tiotidine effectively neutralizes the increase in contractile force facilitated by H2, leaving the negative inotropic responses by H2 unchallenged. It also mitigates the effects of histamine on the A-V node, which include lengthening of the P-R interval and A-V block, at a concentration of 2.5 x 10(-7) M. Furthermore, tiotidine acts as a competitive antagonist against the positive chronotropic effects of histamine, presenting an apparent dissociation constant of 30 μM (23-38 μM). Additionally, tiotidine displays inverse agonist activity in U-937 cells by reducing basal cAMP levels. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Tiotidine | ICI-125211 | ICI125211 | H3 Receptor | H2 Receptor | H1 receptor |
| Inhibitors Related | Undecane | Betahistine mesylate | Histamine dihydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Nizatidine | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
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$119.00
|
VIP2Y
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TargetMol Chemicals Inc.
|
2025-07-19 |
United States