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Postion:Product Catalog >VBIT-4
VBIT-4
  • VBIT-4

VBIT-4 NEW

Price $68 $163 $289
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: VBIT-4 CAS No.: 2086257-77-2
Purity: 99.97% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameVBIT-4
DescriptionVBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).
In vitroVBIT-4 targets the mitochondrial protein VDAC1, inhibits apoptosis and defends against mitochondrial dysfunction. VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis (in HEK-293 cells , IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively).VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention.
In vivoMETHODS: To test the effect on Alzheimer's disease, VBIT-4 (25 mg/kg) was injected intraperitoneally into APP/PS1 mice once daily for four weeks. RESULTS: VDAC1 was significantly up-regulated in APP/PS1 mice and decreased after VBIT-4 treatment; GPX4 expression was decreased in APP/PS1 mice and restored by VBIT-4 treatment; MWM test showed that APP/PS1 mice had a longer latency to find the plateau; VBIT-4 treatment significantly decreased the latency to find the plateau in APP/PS1 mice. VBIT-4 treatment significantly reduced the latency of platform finding in APP/PS1 mice. [3]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 245 mg/mL (535.09 mM), Sonication is recommended.
5% DMSO+40% PEG300+5% Tween 80+50% Saline : 2 mg/mL (4.37 mM)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.5 mg/mL (9.83 mM), Solution.
KeywordsVDAC1 | VBIT-4 | VBIT4 | VBIT 4
Inhibitors RelatedErastin | NSC 15364 | Ferroptosis-IN-20 | SW016789 | VBIT-12 | DIDS | Tuvatexib | AKOS-22 | VBIT-3 | WEHI-9625 | DIDS sodium salt
Related Compound LibrariesApoptosis Compound Library | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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