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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>VGX-1027
VGX-1027
  • VGX-1027

VGX-1027 NEW

Price $41 $85 $137
Package 10mg 25mg 50mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: VGX-1027 CAS No.: 6501-72-0
Purity: 99.86% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameVGX-1027
DescriptionVGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
In vitroVGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas.
In vivoVGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 20.5 mg/mL (99.9 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.75 mM), Sonication is recommended.
KeywordsVGX-1027 | Tumor Necrosis Factor Receptor | TNF-α | TNFR | TNF Receptor | Interleukin Related | Interleukin | Inhibitor | inhibit | ILReceptor | IL-1β | IL-10 | IL Receptor | GIT-27 | GIT27
Inhibitors RelatedKaolin | Ethyl palmitate | Rhamnose monohydrate | Gum arabic | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose | 1,8-Cineole | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Gluconate Calcium | Magnesium sulfate
Related Compound LibrariesNonsteroidal Anti-Inflammatory Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Diabetic Compound Library | Pyroptosis Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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