Product Details
| Product Name:
YM-264 |
CAS No.:
131888-54-5 |
| Supply Ability:
10g |
Release date:
2026/07/16 |
Product Introduction
Bioactivity
| Name | YM-264 |
| Description | YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes). |
| In vitro | YM-264 inhibits [3H] platelet-activating factor binding to rabbit platelet membranes with a pKivalue of 8.85. YM-264 inhibits the platelet-activating factor-induced human, rabbit and guinea-pig platelet aggregation with pA2 values of 8.68, 8.33 and 8.14, respectively[1]. |
| In vivo | Antigen exposure-induced airway hyperresponsiveness is significantly reduced with YM-264 administration. The control group shows a baseline airway resistance (Rrs) value of 0.40 (0.02) cm H2O/mL/s (n=6), compared to YM-264 treated groups which exhibit baseline Rrs values of 0.39 (0.01) cm H2O/mL/s for 1 mg/kg (n=5) and 0.36 (0.01) cm H2O/mL/s for 3 mg/kg (n=6). During immediate allergic reactions, Rrs notably increases to 0.92 (0.10) cm H2O/mL/s in the control (p=0.0002), contrasted with lesser increases of 0.81 (0.12) cm H2O/mL/s at 1 mg/kg (p=0.01) and 1.06 (0.29) cm H2O/mL/s at 3 mg/kg (p=0.048) in the YM-264 treated groups. Furthermore, a significant re-elevation of Rrs to 0.72 (0.10) cm H2O/mL/s (p=0.0101) from baseline is observed in the control group 6 hours post-antigen challenge, whereas YM-264 at doses of 1 and 3 mg/kg markedly inhibits this rise in comparison. Additionally, YM-264 demonstrates a dose-dependent inhibition of eosinophil infiltration. |
| Storage | Keep away from moisture,
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | YM-264 | YM264 | YM 264 | PAF, rabbit platelet membranes |
| Inhibitors Related | Cedrol | Ginkgolide B | PAF C-18 | (Rac)-Modipafant | CP 96021 | Rupatadine | 48740 RP | SDZ-62-434 | Rocepafant | Rupatadine Fumarate | 2-Acetylbenzoic acid | Dersalazine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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