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Postion:Product Catalog >ZM223
ZM223
  • ZM223

ZM223 NEW

Price $70 $161 $236
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-07-04

Product Details

Product Name: ZM223 CAS No.: 2031177-48-5
Purity: 99.73% Supply Ability: 10g
Release date: 2026/07/04

Product Introduction

Bioactivity

NameZM223
DescriptionZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
In vitroZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.57 mM), Sonication is recommended.
DMSO : 80 mg/mL (159.19 mM), Sonication is recommended.
KeywordsZM223 | ZM 223 | NEDD8 activating enzyme (NAE) | NAE | E3Enzyme | E3 Enzyme | E2Enzyme | E2 Enzyme | E1Enzyme | E1 Enzyme
Inhibitors RelatedT521 | PYZD-4409 | NAcM-OPT | Nutlin-3 | Yucasin | BC-1293 | EN219 | NSC232003 | Auxinole | Indole-3-carbinol | Idasanutlin | TRIM25 ligand-1
Related Compound LibrariesBioactive Compound Library | Ubiquitination Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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