文獻(xiàn)引用產(chǎn)品：小鼠抗雙鏈DNA抗體（dsDNA-Ab） ELISA 試劑盒

??文章標(biāo)題：Immunomodulatory effects of atorvastatin on MRL/lpr mice

作者列表：Sun Jing, Xu Weidong, Wu Zhiying, Cao Caijin, Tan Yane, Zhu Meifang, Wu Hongze, Yu Jianping

影響因子：3.01

期刊：Advances in Rheumatology

發(fā)表時(shí)間：2022-12-5

DOI:10.1186/s42358-022-00282-z

文獻(xiàn)主題：Abstract

Background

Statins have long been extensively prescribed as effective lipid-lowering agents, but statins have also been recognized as novel immunomodulators in recent years. This study was designed to investigate the immunomodulatory effects of atorvastatin on lupus-prone MRL/lpr mice.

Methods

A total of 30 8-week-old female MRL/lpr mice were randomly divided into three groups and orally administered vehicle, atorvastatin orhydroxychloroquine sulfate for 11 weeks. In vivo, the effects of atorvastatin on the survival rate, renal function and spleen index in MRL/lpr mice were examined. Ex vivo, splenic B-cell proliferation was assessed by a Cell Counting Kit-8.

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