馬來酸氨氯地平

CAS號(hào)：
88150-47-4

產(chǎn)品介紹：
馬來酸氨氯地平是一種鈣通道阻斷劑，能有效的治療心絞痛和高血壓。它能抑制細(xì)胞外鈣離子跨心肌和血管平滑肌細(xì)胞膜的涌入，導(dǎo)致細(xì)胞內(nèi)鈣離子減少，從而抑制心肌平滑肌細(xì)胞的收縮過程，引起冠狀動(dòng)脈及全身動(dòng)脈擴(kuò)張，增加氧氣輸送到心肌組織，降低總外周阻力，降低全身血壓，減少負(fù)荷。另一種可能的機(jī)制是氨氯地平引起的pH值連續(xù)增高，從而抑制血管平滑肌的碳酸酐酶I的活力，這可能與通過鈣離子通道的胞內(nèi)鈣離子內(nèi)流有關(guān)的活動(dòng)。

先聲藥業(yè)的帕洛諾司瓊原料藥：
先聲藥業(yè)的馬來酸氨氯地平原料藥和制劑成功通過了SFDA的GMP認(rèn)證。制劑商品名為“寧立平”。

一些產(chǎn)品參數(shù)
產(chǎn)品標(biāo)準(zhǔn) CP
性    狀 類白色結(jié)晶性粉末
熔    點(diǎn) 173-174℃（分解）
干燥失重 0.2%
熾灼殘?jiān)?nbsp;小于0.2%
重 金 屬 小于20ppm
含量      99.9%
包裝規(guī)格 20kg/桶

關(guān)鍵詞:  馬來酸氨氯地平,氨氯地平, 88150-47-4，絡(luò)活喜

Amlodipine Maleate

CAS:
88150-47-4

Introduction:
Amlodipine Maleate is a calcium channel blocking agent，and It is effective in the treatment of angina pectoris and hypertension. It inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity with consecutive pH increase which may be involved in intracelluar calcium influx through calcium channels.

Simcere's Amlodipine Maleate API:
Simcere’s API and preparations of Amlodipine Maleate are both successfully passed and received SFDA GMP certification. Its brand name is Ningliping.

Some inspection data
Specification     CP
Properties       Almost white crystalline powder
Meeting Point     173~174℃(Decomposed)
Loss on drying    0.2 %
Residue on ignition 0.2% max
Heavy metals     20 ppm max
Assay            99.9 %
Package          20 kg/drum
 
Keyword: Amlodipine Maleate, Amlodipine, 88150-47-4，Norvasc