| 中文名 | 卡那霉素B
|
| 英文名 | bekanamycin
|
| 別名 | 卡那霉素B
卡那霉素 B
卡那霉素雜質B
卡那霉素雜質3
妥布霉素 EPA
妥布霉素EP雜質A
(2R,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,2S,3S,4R,6S)-4,6-二氨基-3-(((2S ,3R,4S,5S,6R)-4-氨基-3,5-二羥基-6-(羥甲基)四氫-2H-吡喃-2-基)氧基)-2-羥基環(huán)己基)氧基)四氫-2H-吡喃- 3,4-二醇
|
| 英文別名 | kdm
NK 1006
nebramycinv
Bekanamycin
bekanamycin
Kanamycin B
kanendomycin
nebramycinfactor5
Nebramycin factor 5
d-streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(2,6-diamino-2,
4,6-diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside
(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol
|
| CAS | 4696-76-8
|
| EINECS | 225-170-5 |
| 化學式 | C18H37N5O10
|
| 分子量 | 483.51 |
| InChI | InChI=1/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2 |
| 密度 | 1.3771 (rough estimate) |
| 熔點 | 178-182° (dec) |
| 沸點 | 580.49°C (rough estimate) |
| 比旋光度 | D18 +130° (c = 0.5 in water); D21 +114° (c = 0.98 in water) |
| 閃點 | 442.3°C |
| 蒸汽壓 | 3.43E-30mmHg at 25°C |
| 溶解度 | Aqueous Acid (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Sparingl |
| 折射率 | 1.7600 (estimate) |
| 酸度系數(shù) | 13.07±0.70(Predicted) |
| 存儲條件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 穩(wěn)定性 | Hygroscopic |
| 外觀 | Solid |
| 顏色 | Crystals |
| 產(chǎn)品用途 | 為抗生素類藥，也是生產(chǎn)硫酸地貝卡星和硫酸阿貝卡星的中間體 |
| 體外研究 | Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus . Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals. |
| 上游原料 | 營養(yǎng)肉湯(NB) |
| 下游產(chǎn)品 | 阿貝卡星 |