中文名：格列美脲

英文名：Glimepiride

應(yīng)用：A third generation sulfonylurea compound that induces the PI3K and Akt pathway

純度：Moligand?，≥99%

貨號：G129354

Cas號：93479-97-1

存儲溫度：-20°C儲存

運輸條件：超低溫運輸

產(chǎn)品介紹：

Glimepiride is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle sμggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thoμght to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker.A third generation sulfonylurea compound that induces the PI3K and Akt pathway

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