中文名：4-羥基喹唑啉

英文名：4-Hydroxyquinazoline

應(yīng)用：

純度：≥98%(HPLC)

貨號：H157172

Cas號：491-36-1

存儲溫度：室溫

運(yùn)輸條件：常規(guī)運(yùn)輸

產(chǎn)品介紹：

Product Application：

4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

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