中文名：9-ING-41
英文名：9-ING-41
純度：Moligand?，≥98%
貨號：I414423
Cas號：1034895-42-5
存儲溫度：-20°C儲存
運輸條件：超低溫運輸
產(chǎn)品介紹：
Information
9-ing-41 9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
Targets
GSK-3
In vitro
9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
In vivo
9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.
Cell Research(from reference)
Cell lines：Neuroblastoma cell lines SK-N-DZ, SK-N-BE?
Concentrations：0.1 μM–1 μM?
Incubation Time：48 h?
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關(guān)鍵字： 3-(5-FLUORO-1-BENZOFURAN-3-YL)-4-(5-METHYL-5H- (1,3)DIOXOLO(4,5-F)INDOL-7-YL)-1H-PYRROLE-2,5-DIONE ; WHO 11553 ; 2-(hydroxymethyl)-isoindole-1,3-dione ; ND1SOF0DLU
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