中文名：MKC8866
英文名：MKC8866
純度：Moligand?，≥97%
貨號：M414235
Cas號：1338934-59-0
存儲溫度：-20°C儲存
運輸條件：超低溫運輸
產(chǎn)品介紹：
Information
MKC8866 MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29?μM for human IRE1α in vitro.
Targets
hIRE1α (Cell-free assay) 0.29 μM
In vitro
MKC8866 is optimized and refined from a family of IRE1α-specific endoribonuclease inhibitors obtained from a chemical library screen. MKC8866 effectively represses IRE1α-mediated XBP1 splicing in PCa cells and has favorable pharmacokinetic and pharmacodynamic properties.
In vivo
MKC8866 is an IRE1α RNase-specific inhibitor molecule that displays significant therapeutic activity in various preclinical models of PCa in vivo. MKC8866 synergizes with clinical PCa drugs in vivo.
Cell Research(from reference)
Cell lines：human PCa cell lines LNCaP and 22Rv1, VCaP cell line, C4-2B cell line?
Concentrations：0.2-10 μM?
Incubation Time：0.25-24 h?
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關鍵字： 7-羥基-6-甲氧基-4-甲基-3-(2-嗎啉-2-氧乙基)-2-氧代-2H-苯并吡喃-8-醛;s8875 ; MKC8866 ; MKC-8866
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