中文名：AS2863619
英文名：AS2863619
純度：≥98%
貨號(hào)：A414258
Cas號(hào)：2241300-51-4
存儲(chǔ)溫度：-20°C儲(chǔ)存,充氬
運(yùn)輸條件：超低溫運(yùn)輸
產(chǎn)品介紹：
Information
AS2863619 AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in T conv cells.
Targets
CDK8 (Cell-free assay); CDK19 (Cell-free assay) 0.6099 nM; 4.277 nM
In vitro
AS2863619 induction of Foxp3 in vitro does not require exogenous TGF-β. AS2863619-induced iTreg cells can be induced in the presence of inflammatory cytokines such as IL-4, IL-6, and IFN-γ, which appear to hamper Foxp3 gene activation via activation of STATs. AS2863619 is able to generate iTreg cells not only from na?ve Tconv cells but also from effector/memory Tconv cells. Furthermore, AS2863619 cannot induce Foxp3 in CDK8 and CDK19 double-deficient T cells. AS2863619-induced iTreg cells require TCR and IL-2 stimulation for their generation and are devoid of Treg-type DNA hypomethylation, which is present in nTreg cells and required for stable Treg function.
In vivo
AS2863619 induces in vivo Foxp3 induction in antigen-activated T cells. In vivo AS2863619-induced Foxp3+ T cells are able to gradually acquire Treg-specific epigenetic alterations, differentiating into functionally stable Foxp3+ pTreg cells having a more nTreg-like gene expression profile.
Cell Research(from reference)
Cell lines：PBMCs, Human CD4+ T cells, lymph node cells derived from eFox mice?
Concentrations：1.0 μM?
Incubation Time：24 h, 0-44 h?
查看阿拉丁官網(wǎng)此產(chǎn)品相關(guān)對(duì)應(yīng)頁(yè)面：https://www.aladdin-e.com/zh_cn/A414258.html
關(guān)鍵字： 1,?2,?5-?Oxadiazol-?3-?amine,4-?[1-?(2-?methyl-?1H-?benzimidazol-?6-?yl)?-?1H-?imidazo[4,?5-?c]?pyridin-?2-?yl]?-?,hydrochloride (1:2)
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代碼：688179），專注于科研試劑的研發(fā)、生產(chǎn)和銷售，已陸續(xù)建立多個(gè)工廠和研發(fā)中心。作為領(lǐng)軍企業(yè)，阿拉丁始終堅(jiān)持質(zhì)量第一，連續(xù)13年被評(píng)為“最受歡迎試劑品牌”。
阿拉丁目前常備庫(kù)存試劑產(chǎn)品品種超過(guò)7萬(wàn)種，SKU總數(shù)超過(guò)46萬(wàn)，產(chǎn)品線涵蓋了化學(xué)試劑、生化試劑、藥靶配體、蛋白質(zhì)和抗體等多個(gè)領(lǐng)域，是國(guó)內(nèi)少數(shù)化學(xué)試劑到生物試劑全面發(fā)展的國(guó)產(chǎn)試劑品牌，產(chǎn)品同步發(fā)布在我們國(guó)內(nèi)外電商平臺(tái)。