DNAM1產(chǎn)品信息

物種：Human / Mouse / Cynomolgus / Canine

屬性：Protein

標(biāo)記：Biotin-labeled / Unconjugated

分子別名（Synonym）

DNAM1,CD226,PTA1

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

DNAM1分子背景

DNAX輔助分子1（DNAM-1）是一種單程I型膜蛋白，也被稱為CD226抗原和血小板和T細(xì)胞活化抗原1（PTA1），其中含有2個(gè)Ig樣C2型（免疫球蛋白樣）結(jié)構(gòu)域。DNAM-1是一種約65 kDa的糖蛋白，在自然殺傷細(xì)胞、血小板、單核細(xì)胞和T細(xì)胞亞群的表面表達(dá)。DNAM-1介導(dǎo)細(xì)胞與攜帶其配體CD112和CD155的其他細(xì)胞的粘附，并將DNAM-1與抗體交聯(lián)導(dǎo)致細(xì)胞活化。此外，DNAM-1可以與PVR和PVRL2相互作用。