IL-18BP產(chǎn)品信息

英文名稱：Interleukin-18-binding protein

靶點別稱：IL18BP,IL18BPa,Tadekinig-alfa

物種：Human

標(biāo)簽：His Tag / Fc Tag

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

IL-18BP分子背景

白細(xì)胞介素-18結(jié)合蛋白（IL18BP）也被稱為Tadekinig alfa，IL18BPa，其功能是IL18抑制劑。IL18BP是一種分泌型蛋白，含有一個Ig樣C2型（免疫球蛋白樣）結(jié)構(gòu)域。IL18BP沒有跨膜結(jié)構(gòu)域，因此沒有錨定在細(xì)胞膜上。IL18BP在心臟、肺、胎盤和脾臟中強烈表達(dá)。IL18BP的異構(gòu)體A與IL-18結(jié)合并抑制其活性。IL18BP還可以作為早期TH1細(xì)胞因子反應(yīng)的抑制劑。IL18BP抑制IFN-γ的產(chǎn)生，導(dǎo)致T輔助1型免疫反應(yīng)減少。