Typical Specification
Appearance : A white crystalline powder
Solubility : Freely soluble in water and in glacial acetic acid, practically
insoluble in alcohol and in acetone
pH : 7.0-8.0
Related substance
Impurity A : ≤ 0.1%
Impurity B : ≤ 0.2%
Any other impurity : ≤ 0.1%
All other Impurities : ≤ 0.2%
Bromic : Not more than 670ppm
Assay : 99.0-101.0%
Functions
1 Whitening and prevent pigmentation
? Reduce or remove the pigmentation of skin
Prevent and/or treat pigmentations such as chloasmas, freckles, sunburn, dark
skin and melanoderma caused by a drug such as steroid
2
? Minimize dark spot area due to sun exposure.
? Anti-inflammation
Act on the chronic mild inflammatory condition at the sites of spots, to suppress
melanocyte activation
2 Inhibit or improve skin roughness
Restore damaged skin caused by UVA/UVB, pollution or other environmental
factors.
Mechanism of whitening skin
? Block melanin formation path induced by ultraviolet rays
? Prevent melanin accumulation
? Decreases melanocyte tyrosinase activity by preventing the binding of plasminogen
to the keratinocytes, which results in reduction of prostaglandins and arachidonic
acid, which are inflammatory mediators involved in melanogenesis.
Synergistic effects with other whitening ingredients
Tranexamic acid produces good synergistic effect when combined with ascorbic acid
or its derivatives such as magnesium ascorbyl phosphate, 3-O-ethyl ascorbic acid,
disodium adenosine triphophate, escinol (deacylated product of escin under hydrolysis
by sodium methylate), L-cysteine. Penetration enhancers helps the transdermic
absorption of tranexamic acid into spots.
Application
Tranexamic acid is suitable to all kinds of skin for removing pigmentation, whitening
skin and reducing spots, such as:
? Pigmentation after sun exposure
? Dark spots
? Sensitive skin
? Acne and inflammation
? Postoperative care after laser, pulsed light treatment