吲哚莫德|T6543|TargetMol

1篇文獻(xiàn)

價(jià)格	￥463	￥153	￥128
包裝	500mg	100mg	50mg

最小起訂量	50mg
發(fā)貨地	上海
更新日期	2026-05-08

QQ交談微信洽談

產(chǎn)品詳情

中文名稱:吲哚莫德	英文名稱:Indoximod
CAS:110117-83-4	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
純度規(guī)格: 99.55%	產(chǎn)品類別: 抑制劑
貨號: T001\|T6543

Product Introduction

Bioactivity

名稱	Indoximod
描述	Indoximod (NLG-8189) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
激酶實(shí)驗(yàn)	1MT enantiomers are solubilized in DMSO containing 0.1N HCl and added at concentrations of 100, 50, and 0 μM to wells containing the reaction mixture with tryptophan (0-200 μM) followed by addition of IDO enzyme. Plates are sealed and incubated 1 hr in a humidified 37°C incubator, after which the reactions are terminated by addition of 12.5 μl 30% TCA per well. Plates are then resealed in plastic wrap, incubated 30 min at 50°C to hydrolyze the reaction product N-formylkynurenine to kynurenine, and centrifuged. Supernatants are transferred to a flat-bottom 96-well plate, mixed with 100 μl Ehrlich reagent and incubated 10 min at room temperature. Absorbance at 490 nm is read[1].
體外活性	Indoximod significantly reverses the suppression of T cells created by IDO-expressing dendritic cells, using both human monocyte-derived dendritic cells and murine dendritic cells isolated directly from tumor-draining lymph nodes. [1] Indoximod activates a Trp sufficiency signal that stimulates mTOR, and relieves IDO-induced Trp deprivation as well as an autophagic response. [2]
體內(nèi)活性	In mouse models of transplantable melanoma and transplantable and autochthonous breast cancer, Indoximod (400 mg/kg p.o.) enhances antitumor immunity in the setting of combined chemo-immunotherapy regimens. [1]
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : Slightly soluble H2O : < 1 mg/mL (insoluble)
關(guān)鍵字	tryptophan \| Trp mimetic \| NLG8189 \| NLG 8189 \| mTORC1 \| Inhibitor \| inhibit \| Indoximod \| Indoleamine2,3Dioxygenase(IDO) \| Indoleamine2,3Dioxygenase \| Indoleamine 2,3-Dioxygenase (IDO) \| Indoleamine 2,3Dioxygenase (IDO) \| Indoleamine 2,3-Dioxygenase \| immunotherapeutic vaccines \| IDO \| cancer
相關(guān)產(chǎn)品	IDO-IN-12 \| Palmatine \| TDO-IN-1 \| Coptisine chloride \| GNF-PF-3777 \| Necrostatin-1 \| IDO-IN-7 \| IDO1-IN-28 \| Epacadostat \| 3-TYP \| Palmatine chloride \| β-Lapachone
相關(guān)庫	抑制劑庫 \| 經(jīng)典已知活性庫 \| 抗癌活性化合物庫 \| 已知活性化合物庫 \| 臨床失敗化合物庫 \| 抗肺癌化合物庫 \| 免疫/炎癥分子化合物庫 \| 藥物功能重定位化合物庫 \| 抗癌臨床化合物庫 \| 表型篩選靶點(diǎn)鑒定庫 \| 人代謝物化合物庫 \| 抗癌藥物庫

關(guān)鍵字：吲哚莫德;NLG-8189;Indoximod (NLG-8189);1-Methyl-D-tryptophan;TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對明確靶點(diǎn)的分子篩選到對明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （14年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 14年

公司成立：14年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

進(jìn)入店鋪

詢盤

店內(nèi)推薦

普卡那肽|T9080|TargetMol

詢價(jià)

5,6-二甲氧基-2-(4-哌啶基)亞甲基-1-茚酮|T80671|TargetMol

￥115

厚樸酚|T3000|TargetMol

￥255