PE-Labeled Monoclonal Anti-Human IL-15 Antibody, Mouse IgG1 (12B11E5) (0.03% Proclin)
抗體來源（Source）
Monoclonal Anti-human IL-15 Antibody, Mouse IgG1 (12B11E5) is a mouse monoclonal antibody recombinantly expressed from human 293 cells (HEK293)，which provides higher batch consistency and long term security of supply.
應(yīng)用（Application）
Flow Cytometry (Detection the expression of IL-15 on CAR-NK)
克隆號(hào)（Clone）
12B11E5
種屬（Species）
Mouse
亞型（Isotype）
Mouse IgG1 | Mouse Kappa
特異性（Specificity）
This product is a specific antibody specifically reacts with Human IL-15.
種屬反應(yīng)性（Reactivity）
Human
免疫原（Immunogen）
Recombinant Human IL-15 is expressed from human HEK293 cells.
偶聯(lián)（Conjugate）
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
同型對(duì)照（Isotype Control）
The Isotype control is sold separately and you can search for Cat. No. DNP-PM1 for product information.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.3, 0.2% BSA, 0.03% Proclin300 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 12 months after reconstitution.
2-8 °C for 12 months after reconstitution.
背景（Background）
Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
關(guān)鍵字： IL-15抗體;IL-15單克隆抗體;Anti-IL-15;百普賽斯;ACRO;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。