化合物 MM-102|T6333|TargetMol

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價(jià)格	￥427	￥619	￥1270
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2026-04-02

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產(chǎn)品詳情

中文名稱:化合物 MM-102	英文名稱:MM-102
CAS:1417329-24-8	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
純度規(guī)格: 99.99%	產(chǎn)品類別: 抑制劑
貨號(hào): T001\|T6333

Product Introduction

Bioactivity

名稱	MM-102
描述	MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay. MM-102 can also specifically inhibit cell growth and induce apoptosis in leukemia cells carrying MLL1 fusion protein.
細(xì)胞實(shí)驗(yàn)	MV4;11, KOPN8, and K562 cells are cultured in RPMI 1640 medium (ATCC) supplemented with 10% fetal bovine serum and 100 U/L penicillin-streptomycin and incubated at 37 °C under 5% CO2. Cells are seeded into 12-well plates for suspension at a density of 5 × 105 per well (1 mL) and treated with either vehicle control (DMSO, 0.2%) or MM-102 for 7 days. The medium is changed every 2 days, and compounds are resupplied. The CellTiter-Glo Luminescent Cell Viability Assay kit is used following the manufacturer’s instruction. First, 100 μL of the assay reagent is added into each well, and the content is mixed for 2 min on an orbital shaker to induce cell lysis. After 10 min incubation at room temperature, the luminescence is read on a microplate reader. (Only for Reference)
激酶實(shí)驗(yàn)	In Vitro Histone Methyltransferase (HMT) Assay: The HMT assay is performed in 50 mM HEPES pH 7.8, 100 mM NaCl, 1.0 mM EDTA, and 5% glycerol at 22 °C. Each reaction contains 1.5 μCi of the co-factor, 3H-S-adenosylmethionine. H3 10-residue peptide is used as the substrate at 50 μM. Compounds are added at concentrations ranging from 0.125 to 128 μM and incubated with the pre-assembled WDR5/RbBP5/ASH2L complex at a final concentration of 0.5 μM for each protein for 2–5 min. Reactions are initiated by addition of the MLL1 protein at a final concentration of 0.5 μM and allowed to proceed for 30 min before preparing scintillation counting. To count samples, reactions are spotted on separate squares of P81 filter paper and precipitated by submerging in freshly prepared 50 mM sodium bicarbonate buffer with pH 9.0. After washing and drying, samples are vortexed in Ultima Gold scintillation fluid and counted. As a negative control, assays are performed using 0.5 μM MLL1/WDR5/RbBP5/ASH2L complex assembled with the non-interacting mutant, WDR5D107A.
體外活性	方法：用 MM-102 (HMTase Inhibitor IX) （25,50μM）處理 MLL1-AF9 轉(zhuǎn)導(dǎo)的小鼠細(xì)胞，然后用定量 RT-PCR （QRT-PCR）進(jìn)行基因表達(dá)分析。結(jié)果：MM-102 以劑量依賴性方式降低 HoxA9 mRNA 的表達(dá) MM-102 在 50 μM 時(shí) Meis-1 表達(dá)明顯下降，MM-102不影響管家基因GAPDH的表達(dá)。[1] 方法：用 20 μM MM-102（20 μM ，20小時(shí)）預(yù)處理細(xì)胞 24 小時(shí)，然后用 500 μM SNP 孵育，約24小時(shí)后評(píng)估細(xì)胞凋亡活性。結(jié)果：SNP顯著刺激軟骨細(xì)胞凋亡，而用MM-102預(yù)處理的細(xì)胞減輕了SNP刺激軟骨細(xì)胞凋亡，MM-102預(yù)處理有效挽救了FSS對軟骨細(xì)胞的負(fù)面影響，這可能為基于表觀遺傳學(xué)的OA治療奠定基礎(chǔ)。[2]
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+90% Saline : < 10 mg/mL (14.93 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. DMSO : 140 mg/mL (209.02 mM), Sonication is recommended. H2O : 92 mg/mL (137.35 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (14.93 mM), Solution. Ethanol : 93 mg/mL (138.85 mM), Sonication is recommended.
關(guān)鍵字	MM-102 \| MM 102 \| MLL1 \| Inhibitor \| inhibit \| HistoneMethyltransferase \| Histone Methyltransferase
相關(guān)產(chǎn)品	Formamide \| Urea \| D-Psicose \| Kaolin \| Aceglutamide \| Alginic acid \| Metronidazole \| Stavudine \| Gluconate Calcium \| D(+)-Raffinose pentahydrate \| Ethyl linoleate \| Hydroxypropyl Cellulose
相關(guān)庫	抑制劑庫 \| 經(jīng)典已知活性庫 \| 抗癌化合物庫 \| 已知活性化合物庫 \| 組蛋白修飾化合物庫 \| 含氟化合物庫 \| 表觀遺傳庫 \| NO PAINS 化合物庫 \| 免疫/炎癥分子化合物庫 \| 膜蛋白靶向化合物庫 \| NF-κB 通路分子庫 \| PPI抑制劑庫

關(guān)鍵字： MM102;HMTase Inhibitor IX;TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （14年）	注冊資本	566.265100萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

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公司成立：14年
注冊資本：566.265100萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑、藥物篩選化合物庫、藥物篩選等
公司地址：靜安區(qū)江場三路238號(hào)8樓

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