化合物 UNC1215|T2379|TargetMol

價(jià)格	￥245	￥329	￥496
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2026-06-29

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產(chǎn)品詳情

中文名稱:化合物 UNC1215	英文名稱:UNC1215
CAS:1415800-43-9	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
純度規(guī)格: 98.00%	產(chǎn)品類別: 抑制劑
貨號(hào): T001\|T2379

Product Introduction

Bioactivity

名稱	UNC1215
描述	UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC₅₀/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold higher versus other members of the human MBT family.
細(xì)胞實(shí)驗(yàn)	CellTiter-Glo luminescent cell viability assay(Only for Reference)
激酶實(shí)驗(yàn)	AlphaScreen assay: Compound plates (1 μL at 10 or 30 mM highest concentration) are diluted in 1×assay buffer (20 mM Tris pH 8.0, 25 mM NaCl, 2 mM DTT and 0.05% Tween-20) over 2 steps using a Multimek robotic pipettor and 1 μL is spotted into the wells of 384-well assay Proxiplates. To these plates 9 μL of protein- peptide mix in 1× assay buffer is added by Multidrop and incubated for 30 min at room temperature. At this point 2 μL of streptavidin-conjugate donor and nickel-chelate acceptor beads (45 μg/mL in 1× assay buffer) are added, the plates are allowed to incubate for an additional 30 min in the dark at room temperature. After incubation the plates are read on EnVision mulilabel reader equipped with HTS alpha screen laser. The screens reported are performed up to 10 or 30 μM, and therefore it should be noted that those compounds referred to as inactive are indeed inactive only within the concentration range tested. PHF23 and JARID1A are GST tagged and consequently for these assays GST-acceptor beads are used. It should be noted that any positive binding curves for L3MBTL4 that are generated yielded curves with very shallow slopes, suggesting a nonspecific interaction. The data for the IC50 values is calculated from replicate runs in that the datapoints for each compound concentration are averaged and plotted using 4-parameters curve fitting.
體內(nèi)活性	UNC1215與L3MBTL3結(jié)合,競(jìng)爭(zhēng)性置換含單或二甲基賴氨酸的肽段。UNC1215對(duì)L3MBTL3的選擇性比L3MBTL1高約75倍。UNC1215無(wú)細(xì)胞毒性,通過(guò)MBT域的Kme結(jié)合口袋,直接結(jié)合到L3MBTL3。UNC1215使GFP-L3MBTL3融合蛋白的細(xì)胞移動(dòng)性與點(diǎn)突變?cè)黾?干擾GFP-L3MBTL3表型模擬的Kme結(jié)合功能,影響UNC1215的定位。UNC1215（30 μM）不影響UHRF1的串聯(lián)Tudor域、CBX7的染色質(zhì)域及JARID1A的PHD域。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 122.5 mg/mL (231.25 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 93 mg/mL (175.56 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (1.89 mM), Sonication is recommended. 10% DMSO+90% Saline : 10 mg/mL (18.88 mM), Suspension.
關(guān)鍵字	UNC-1215 \| UNC1215 \| UNC 1215 \| probe \| methyllysine \| MBT \| Malignant \| L3MBTL3-D274A \| L3MBTL3 \| Inhibitor \| inhibit \| HistoneMethyltransferase \| Histone Methyltransferase \| EpigeneticReaderDomain \| Epigenetic Reader Domain \| Cerebrum \| Apoptosis
相關(guān)產(chǎn)品	Formamide \| Urea \| Sodium Molybdate \| Dimethyl phthalate \| Aceglutamide \| Alginic acid \| Cysteamine hydrochloride \| Metronidazole \| Sildenafil citrate \| Citric Acid Triammonium \| Stavudine \| Tamoxifen
相關(guān)庫(kù)	抑制劑庫(kù) \| 經(jīng)典已知活性庫(kù) \| 抗癌活性化合物庫(kù) \| 已知活性化合物庫(kù) \| 染色質(zhì)修飾分子庫(kù) \| 組蛋白修飾化合物庫(kù) \| 細(xì)胞凋亡化合物庫(kù) \| 抗衰老化合物庫(kù) \| NO PAINS 化合物庫(kù) \| 表觀遺傳庫(kù) \| 膜蛋白靶向化合物庫(kù) \| 甲基化化合物庫(kù)

關(guān)鍵字： UNC1215;TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫(kù)和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫(kù)，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （14年）	注冊(cè)資本	566.265100萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù)	經(jīng)營(yíng)模式	貿(mào)易,工廠,試劑,定制,服務(wù)

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公司成立：14年
注冊(cè)資本：566.265100萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑、藥物篩選化合物庫(kù)、藥物篩選等
公司地址：靜安區(qū)江場(chǎng)三路238號(hào)8樓

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