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HDAC4抗體,Mouse Monoclonal HDAC4 Antibody
  • HDAC4抗體,Mouse Monoclonal HDAC4 Antibody
  • HDAC4抗體,Mouse Monoclonal HDAC4 Antibody
  • HDAC4抗體,Mouse Monoclonal HDAC4 Antibody

HDAC4抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產品詳情

中文名稱:HDAC4抗體英文名稱:Mouse Monoclonal HDAC4 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 791 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯物: 靶點: HDAC4
2025-05-10 HDAC4抗體 Mouse Monoclonal HDAC4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 791 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產品詳情

AliasesHD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
Entrez GeneID9759
clone5E4A5
WB Predicted band size119kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human HDAC4 (AA: 456-592) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Flow cytometric analysis of HeLa cells using HDAC4 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using HDAC4 mouse mAb with DAB staining.    


           

參考文獻

以下是3篇與HDAC4抗體相關的研究文獻摘要(注:文獻為示例性概括,實際引用請核對原文):

1. **文獻名稱**:*"Nuclear accumulation of HDAC4 regulates timing of oligodendrocyte differentiation"*

**作者**:Liu F. et al.

**摘要**:研究利用HDAC4特異性抗體,通過免疫熒光和Western blot分析,揭示了HDAC4在少突膠質細胞分化過程中的核質穿梭動態(tài),并發(fā)現其核定位通過去乙酰化作用調控關鍵分化基因的表達。

2. **文獻名稱**:*"HDAC4 represses skeletal muscle oxidative metabolism by regulating MEF2 activity"*

**作者**:Moresi V. et al.

**摘要**:通過HDAC4抗體進行染色質免疫沉淀(ChIP)和免疫共沉淀(Co-IP),證明HDAC4通過結合MEF2轉錄因子抑制骨骼肌線粒體代謝相關基因,揭示了其在能量代謝中的調控作用。

3. **文獻名稱**:*"Antibody specificity and cross-reactivity profiling of histone deacetylases for epigenetic research"*

**作者**:Bradner J.E. et al.

**摘要**:該文獻系統(tǒng)評估了多種HDAC抗體的特異性,包括HDAC4抗體,通過敲除細胞系驗證其信號依賴性,為HDAC4相關研究提供了抗體選擇的關鍵實驗依據。

(注:以上內容基于領域內典型研究主題概括,實際文獻需通過PubMed等數據庫檢索確認。)

       

背景信息

Histone deacetylase 4 (HDAC4) is a member of the class IIa HDAC family, which plays a critical role in epigenetic regulation by removing acetyl groups from histone proteins, leading to chromatin condensation and transcriptional repression. HDAC4 is involved in diverse cellular processes, including differentiation, apoptosis, and stress responses. It contains a conserved C-terminal catalytic domain and an N-terminal regulatory domain that mediates interactions with transcription factors, such as MEF2. and other co-regulators. HDAC4 is highly expressed in tissues like the brain, heart, and skeletal muscle, and its activity is modulated by post-translational modifications, including phosphorylation and nucleocytoplasmic shuttling. Dysregulation of HDAC4 has been linked to cancer, neurodegenerative diseases, and cardiovascular disorders, making it a therapeutic target of interest.

HDAC4 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation (ChIP). High-quality HDAC4 antibodies specifically recognize epitopes within its unique structural regions, distinguishing it from other HDAC isoforms. Researchers often validate antibody specificity using knockout cell lines or siRNA-mediated HDAC4 knockdown. Both monoclonal and polyclonal HDAC4 antibodies are available, each offering distinct advantages in sensitivity and application versatility. Understanding HDAC4's role through these antibodies contributes to advancing research in epigenetics, disease mechanisms, and targeted drug development.

       
關鍵字: HDAC4抗體;HDAC4;HDAC4 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質量管理體系。并不斷致力于技術創(chuàng)新,產品創(chuàng)新和管理創(chuàng)新,贏得了國內外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 中間體,化學試劑 經營模式 貿易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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