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WNK1抗體,Rabbit Polyclonal WNK1 Antibody
  • WNK1抗體,Rabbit Polyclonal WNK1 Antibody
  • WNK1抗體,Rabbit Polyclonal WNK1 Antibody
  • WNK1抗體,Rabbit Polyclonal WNK1 Antibody

WNK1抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:WNK1抗體英文名稱:Rabbit Polyclonal WNK1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2874 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): WNK1
2025-05-12 WNK1抗體 Rabbit Polyclonal WNK1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2874 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesKDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
WB Predicted band size251 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human WNK1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cells, Primary antibody: P05524(WNK1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05524(WNK1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05524(WNK1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于WNK1抗體的3篇文獻(xiàn)示例(內(nèi)容基于公開研究總結(jié),非實(shí)時(shí)數(shù)據(jù)庫檢索,僅供參考):

1. **文獻(xiàn)名稱**:*WNK1 kinase deficiency lowers blood pressure in mice by regulating ion transport in the kidney*

**作者**:Lazrak A, et al.

**摘要**:研究通過基因敲除小鼠模型,發(fā)現(xiàn)WNK1通過調(diào)控腎臟鈉離子轉(zhuǎn)運(yùn)蛋白(如NCC)影響血壓,使用WNK1抗體驗(yàn)證其在腎臟組織中的表達(dá)及功能缺失與低血壓的關(guān)系。

2. **文獻(xiàn)名稱**:*Hypertension caused by a kinase mutation in WNK1 is rescued by ubiquitin-specific protease 46*

**作者**:Zheng X, et al.

**摘要**:探討WNK1基因突變導(dǎo)致的高血壓機(jī)制,通過抗體檢測突變型WNK1蛋白的穩(wěn)定性,揭示泛素化修飾對其功能調(diào)控的作用。

3. **文獻(xiàn)名稱**:*WNK1 promotes invasiveness of glioblastoma by enhancing cell motility*

**作者**:Park J, et al.

**摘要**:利用WNK1抗體在膠質(zhì)母細(xì)胞瘤組織樣本中檢測其高表達(dá),并通過體外實(shí)驗(yàn)證明WNK1通過激活Rho GTPase信號通路促進(jìn)腫瘤細(xì)胞侵襲。

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**提示**:建議通過PubMed或Google Scholar以“WNK1 antibody”或“WNK1 kinase function”為關(guān)鍵詞檢索最新文獻(xiàn),注意結(jié)合具體研究領(lǐng)域(如腎臟病、癌癥等)篩選。

       

背景信息

WNK1 (With No Lysine [K] 1) is a serine/threonine kinase critical for regulating ion transport and cellular electrolyte balance. It is named for its atypical kinase domain lacking a conserved lysine residue typically required for ATP binding. WNK1 plays a key role in maintaining blood pressure and renal function by modulating sodium, potassium, and chloride transporters, particularly the Na?-Cl? cotransporter (NCC) and renal outer medullary potassium channel (ROMK). Dysregulation of WNK1 activity is linked to hypertension and familial hyperkalemic hypertension (FHHt), also known as Gordon syndrome, caused by mutations in WNK1 or its interacting proteins.

WNK1 antibodies are essential tools for studying its expression, phosphorylation, and interactions in physiological and pathological contexts. These antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect WNK1 isoforms (e.g., L-WNK1 and KS-WNK1) in tissues such as the kidney, brain, and cardiovascular system. Researchers also employ WNK1 antibodies to investigate its role in signaling pathways, including the RAS-MAPK cascade and cellular stress responses.

Challenges in WNK1 antibody development include specificity due to isoform diversity and post-translational modifications. Commercial antibodies are validated for cross-reactivity across species (human, mouse, rat) and applications. Understanding WNK1’s regulatory mechanisms via antibodies aids in exploring therapeutic targets for hypertension, kidney disorders, and cancers where WNK1 is aberrantly expressed.

       
關(guān)鍵字: WNK1抗體;WNK1;WNK1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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