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ICAM1抗體,Rabbit Polyclonal ICAM1 Antibody
  • ICAM1抗體,Rabbit Polyclonal ICAM1 Antibody
  • ICAM1抗體,Rabbit Polyclonal ICAM1 Antibody
  • ICAM1抗體,Rabbit Polyclonal ICAM1 Antibody

ICAM1抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ICAM1抗體英文名稱:Rabbit Polyclonal ICAM1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3870 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: ICAM1
2025-05-14 ICAM1抗體 Rabbit Polyclonal ICAM1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3870 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBB2; CD54; P3.58
WB Predicted band size58 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human ICAM1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raji cells, huvec cells, Primary antibody: P07991(ICAM1 Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P07991(ICAM1 Antibody) at dilution 1/50. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07991(ICAM1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻

以下是3篇關于ICAM1抗體的代表性文獻(虛擬示例,僅作參考格式說明):

1. **"Anti-ICAM1 monoclonal antibody attenuates inflammation in murine models of acute lung injury"**

- **作者**: Smith A et al.

- **摘要**: 研究證明抗ICAM1單克隆抗體通過阻斷白細胞-內(nèi)皮細胞黏附,顯著減少中性粒細胞浸潤和促炎因子釋放,改善脂多糖誘導的小鼠急性肺損傷。

2. **"Targeting ICAM1 with antibody-drug conjugates inhibits tumor metastasis in triple-negative breast cancer"**

- **作者**: Chen L et al.

- **摘要**: 開發(fā)了一種靶向ICAM1的抗體-藥物偶聯(lián)物(ADC),在臨床前模型中顯示可特異性識別高表達ICAM1的三陰性乳腺癌細胞,并抑制腫瘤轉(zhuǎn)移。

3. **"ICAM1 blockade reduces viral entry and cytokine storm in COVID-19 organoid models"**

- **作者**: Gupta R et al.

- **摘要**: 發(fā)現(xiàn)抗ICAM1抗體通過干擾新冠病毒刺突蛋白與宿主細胞的相互作用,降低病毒侵入效率,同時減輕類器官模型中的炎癥因子風暴。

如需真實文獻,建議在PubMed或Google Scholar中檢索關鍵詞:**ICAM1 antibody therapeutic/inhibition/inflammation**。

       

背景信息

ICAM-1 (Intercellular Adhesion Molecule-1), also known as CD54. is a cell surface glycoprotein belonging to the immunoglobulin superfamily. It plays a critical role in mediating leukocyte adhesion and transmigration during inflammatory responses by binding to integrins like LFA-1 (lymphocyte function-associated antigen-1) on immune cells. ICAM-1 is constitutively expressed at low levels on endothelial cells, epithelial cells, and certain immune cells, but its expression is strongly upregulated by pro-inflammatory cytokines (e.g., TNF-α, IL-1β) or microbial products during infection, injury, or autoimmune conditions.

ICAM-1 antibodies are valuable tools for research and therapeutic applications. In research, they are used to block ICAM-1 interactions, study leukocyte trafficking mechanisms, or detect ICAM-1 expression in disease models (e.g., atherosclerosis, cancer, rheumatoid arthritis). Therapeutically, anti-ICAM-1 monoclonal antibodies have been explored to dampen pathological inflammation or immune activation. For instance, they may inhibit leukocyte infiltration in organ transplant rejection or autoimmune disorders. Some antibody-drug conjugates or radiolabeled ICAM-1 antibodies are also investigated for targeted delivery in cancer or imaging.

Notably, soluble ICAM-1 (sICAM-1) levels in blood are often monitored as a biomarker of endothelial dysfunction or disease severity. While no ICAM-1-targeted antibody has been fully approved yet, preclinical and clinical studies highlight its potential in modulating immune-driven pathologies. Challenges include balancing efficacy with off-target effects due to ICAM-1's broad expression roles in homeostasis and disease.

       
關鍵字: ICAM1抗體;ICAM1;ICAM1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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