Human IL-11 R alpha Protein, His Tag (MALS verified)
分子別名（Synonym）
IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha
表達區(qū)間及表達系統(tǒng)（Source）
Human IL-11 R alpha, His Tag (ILR-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ala 370 (Accession # Q14626-1).
Predicted N-terminus: Ser 24
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 39.6 kDa. The protein migrates as 47-52 kDa when calibrated against Star Ribbon Pre- stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
純度（Purity）
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景介紹
白細胞介素-11受體（IL11）。IL6、LIF、OSM、CNTF、IL11和CT1的受體系統(tǒng)可利用IL6ST啟動信號傳導。IL11/IL11RA/IL6ST復合物可能參與調(diào)控成骨祖細胞或其他間充質(zhì)細胞的增殖和/或分化（可能）。對顱面骨和牙齒的正常發(fā)育至關(guān)重要，可抑制骨縫過早閉合并調(diào)節(jié)牙齒數(shù)量。可溶性IL11受體（sIL11RA）作為IL11活性的激動劑，其與IL11形成的復合物能結(jié)合細胞表面的IL6ST/gp130，并通過"IL11反式信號傳導"機制在不表達膜結(jié)合型IL11RA的細胞中誘導信號傳導。
關(guān)鍵字： IL-11RA;IL-11RA蛋白;IL-11RA重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。