Human Mucin-1 / MUC-1 (1036-1155) Protein, His Tag
分子別名（Synonym）
Mucin 1, MUC1, CD227, EMA, H23AG, KL-6, MAM6, MUC-1, SEC, MUC-1, X, MUC1, ZD, PEM, PEMT, PUM, CA15-3, Episialin
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Human Mucin-1 (1036-1155), His Tag (MU1-H52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 1036 - Gly 1155 (Accession # P15941-1).
Predicted N-terminus: Leu 1036 (partial α chain) & Ser 1098 (partial β chain)
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 7.2 kDa (partial α chain) and 8.2 kDa (partial β chain). The protein migrates as 8 kDa (partial α chain) and 10-11 kDa (partial β chain) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
純度（Purity）
>90% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景介紹
膜粘蛋白在上皮細(xì)胞中具有多種功能，包括細(xì)胞保護(hù)、轉(zhuǎn)移過(guò)程中的外滲、維持管腔結(jié)構(gòu)以及信號(hào)傳導(dǎo)。MUC17含有延伸的重復(fù)細(xì)胞外糖基化結(jié)構(gòu)域，其羧基末端包含兩個(gè)表皮生長(zhǎng)因子樣結(jié)構(gòu)域、一個(gè)SEA模塊結(jié)構(gòu)域、一個(gè)跨膜結(jié)構(gòu)域，以及一個(gè)具有潛在絲氨酸和酪氨酸磷酸化位點(diǎn)的胞質(zhì)結(jié)構(gòu)域。該蛋白通過(guò)其C末端與PDZK1相互作用，這種相互作用對(duì)其正確定位至關(guān)重要。MUC17可能在維持黏膜表面穩(wěn)態(tài)方面發(fā)揮作用。
關(guān)鍵字： Mucin-1;Mucin-1蛋白;Mucin-1重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國(guó)生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。