Product Name: Parthenolide(PTL)

CAS No.: 20554-84-1

Synonyms:Germacra-1(10),11(13)-dien-12-oic acid, 4,5.alpha.-epoxy-6.beta.-hydroxy-, gamma.-lactone

Chemical Name:

[1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one; 2,3,6,7,7aS,8,10aS,10bR-octahydro-1aR,5-dimethyl-8-methylene-(4E)-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

Molecular Formula: C15H20O3

Molecular Weight: 248.32

Appearance: White to off-white crystalline powder

Purity(HPLC): >99.0%

Biological Activity:

 The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B4 and thromboxane B2.

 Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.