Product Name：Gramicidin A
CAS No.：1405-97-6
Synonyms：短桿菌肽A
Catalog No.：218P141
Brand：Typeptide Biotech（肽研生物）
Description：Gramicidin A是由短芽孢桿菌產(chǎn)生的一種抗生素，為線狀十五肽，N端甲?；忾]氨基，C端是醛基。Gramicidin A能夠殺死某些微生物．兩個(gè)短桿菌肽A分子從膜兩側(cè)相對(duì)插入可形成穿膜通道，提高生物膜對(duì)某些一價(jià)陽離子的通透性，使這些物質(zhì)順濃度梯度通過細(xì)胞膜，不過Gramicidin A并不顯著提高運(yùn)輸速度。研究顯示Gramicidin A能抑制T7噬菌體DNA的轉(zhuǎn)錄，抑制膜結(jié)合的表皮腺苷酸三磷酸酶活性和體外阻抑人淋巴細(xì)胞轉(zhuǎn)化。在大鼠動(dòng)物模型中能延長心臟移植存活率。
Gramicidin A is an antibiotic produced by Bacillus brevis, which is a linear pentadecapeptide with an N-terminal formylated blocked amino group and a C-terminal aldehyde group. Gramicidin A can kill certain microorganisms. Two molecules of gramicidin A insert from opposite sides of the membrane to form a transmembrane channel, enhancing the permeability of biological membranes to certain monovalent cations and allowing these substances to pass through the cell membrane along the concentration gradient. However, gramicidin A does not significantly increase transport speed. Studies have shown that gramicidin A inhibits the transcription of T7 phage DNA, suppresses membrane-bound epidermal adenosine triphosphatase activity, and blocks the transformation of human lymphocytes in vitro. In rat animal models, it can prolong the survival rate of heart transplants.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | For-VGA-d-LA-d-VVVWLW-d-LW-d-LWG-ol |
Sequence(3-letter code) | For-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-Gly-ol |
Peptide Structure | 
|
Molecular Formula | C99H140N20O17 |
Molecular Weight | 1882.3 |
訂購聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： 短桿菌肽A;Gramicidin A;1405-97-6;多肽;多肽合成;
肽研生物坐落于國家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。