Human Claudin-3 Full Length Protein (VLP)
分子別名（Synonym）
C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Human Claudin-3 Full Length Protein (VLP) (CL3-H52P3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Val 220 (Accession # O15551).
Predicted N-terminus: Met 1
蛋白結(jié)構(gòu)（Molecular Characterization）
Virus-like particles(VLPs) are formed by self-assembly of capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
純度（Purity）
>95% as determined by SEC-HPLC.
制劑（Formulation）
The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
運(yùn)輸（Shipping）
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(chǔ)（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 12 months under sterile conditions.
背景介紹
緊密連接是上皮或內(nèi)皮細(xì)胞片中細(xì)胞間黏連的一種方式，它們?cè)诩?xì)胞周?chē)纬蛇B續(xù)的封閉結(jié)構(gòu)，作為物理屏障，阻止溶質(zhì)和水自由通過(guò)細(xì)胞旁間隙。這些連接由面向細(xì)胞質(zhì)的脂質(zhì)雙層外層中一系列連續(xù)的網(wǎng)絡(luò)鏈組成，并在面向細(xì)胞外的脂質(zhì)雙層內(nèi)層中形成互補(bǔ)的溝槽。該基因（無(wú)內(nèi)含子）編碼的蛋白是claudin家族成員，一種整合膜蛋白，也是緊密連接鏈的組成部分。該蛋白同時(shí)也是產(chǎn)氣莢膜梭菌腸毒素的低親和力受體，并且與大鼠中一種推測(cè)的凋亡相關(guān)蛋白具有氨基酸序列相似性。
關(guān)鍵字： Claudin-3;Claudin-3蛋白;Claudin-3重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國(guó)生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。