Product Name：Cenupatide
CAS No.：1006388-38-0
Synonyms：抑制劑Ac-Arg-Aib-Arg-α(Me)Phe-NH2
Catalog No.：218P027
Brand：Typeptide Biotech（肽研生物）
Description：Cenupatide是一種尿激酶纖溶酶原激活物受體 (uPAR) 抑制劑候選藥物，是一條由4個(gè)氨基酸組成的直鏈小分子多肽，序列中含有兩個(gè)非天然氨基酸。Cenupatide抑制uPAR與甲酰肽受體(FPR)的結(jié)合可以改善鏈脲佐菌素(STZ)誘導(dǎo)的糖尿病大鼠模型中的腎臟損傷。實(shí)驗(yàn)發(fā)現(xiàn)Cenupatide可恢復(fù)STZ誘導(dǎo)的uPA水平和活性上調(diào)，而足細(xì)胞上的uPAR和(s)uPAR不受影響。同事在腎小球中，Cenupatide能抑制FPR2表達(dá)，表明該藥物可能作用于下游uPAR，并恢復(fù)了αvβ3整合素/Rac-1 途徑的活性增加，表明uPAR在調(diào)節(jié)足細(xì)胞功能中的主要作用。
Cenupatide is a candidate drug that inhibits the urokinase plasminogen activator receptor (uPAR), a small linear polypeptide composed of four amino acids, with two non-natural amino acids in its sequence. By inhibiting the binding of uPAR to the formyl peptide receptor (FPR), Cenupatide can improve renal damage in a streptozotocin (STZ)-induced diabetic rat model. Experimental findings reveal that Cenupatide restores the upregulation of uPA levels and activity induced by STZ, while uPAR and (s)uPAR on podocytes remain unaffected. Additionally, in the glomeruli, Cenupatide suppresses FPR2 expression, suggesting the drug may act downstream of uPAR and restore the increased activity of the αvβ3 integrin/Rac-1 pathway, indicating uPAR's pivotal role in regulating podocyte function.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-R-Aib-R-N-Me-Phe-NH2 |
Sequence(3-letter code) | Ac-Arg-Aib-Arg-N-Me-Phe-NH2 |
Peptide Structure | 
|
Molecular Formula | C28H47N11O5 |
Molecular Weight | 617.75 |
訂購聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： Cenupatide;抑制劑Ac-Arg-Aib-Arg-α(;1006388-38-0;
肽研生物坐落于國家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。