Product Name：Linaclotide
CAS No.：851199-59-2（free）；851199-60-5（Hac）
Synonyms：linaclotide (usan)；利那洛肽
Catalog No.：218P053
Brand：（珀?duì)柹铮?/span>
Description：Linaclotide是一種鳥(niǎo)苷酸環(huán)化酶C激動(dòng)劑，結(jié)構(gòu)為含14個(gè)氨基酸的多肽。該藥物多肽能通過(guò)與腸道上皮局部的GC-C受體結(jié)合發(fā)揮作用，活化后的GC-C受體誘導(dǎo)體內(nèi)cGMP濃度增加，一方面可以刺激腸液的分泌并促進(jìn)胃腸活動(dòng)，導(dǎo)致患者排便次數(shù)增多；另一方面可以減少痛覺(jué)神經(jīng)活性，進(jìn)而減少患者腸道疼痛。
Linaclotide is a guanylate cyclase C agonist with a structure of a peptide containing 14 amino acids. The drug peptide can play a role by binding to local GC-C receptors in the intestinal epithelium, and the activated GC-C receptors can induce an increase in the concentration of cGMP in the body. On the one hand, it can stimulate the secretion of intestinal fluid and promote gastrointestinal activity, leading to an increase in the number of stools in patients; On the other hand, it can reduce pain sensory nerve activity, thereby reducing intestinal pain in patients.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code)
CCEYCCNPACTGCY(Disulfide bond:Cys1-Cys6, Cys2 -Cys10,Cys5-Cys13)
關(guān)鍵字： 利那洛肽;利那洛肽雜質(zhì)Ⅱ;CY-14;