Product Name：Nesiritide Acetate （BNP-32）
CAS No.：114471-18-0；124584-08-3
Synonyms：奈西立肽；BNP (1-32), HUMAN；brain natriuretic peptide-32
Catalog No.：177P19
Description：Nesiritide Acetate是一條含有32個(gè)氨基酸的多肽，最先是利用重組DNA技術(shù)從大腸桿菌(Escherichiacoli)中獲得的合成型人類(lèi)腦利鈉肽(brainnatriureticpeptide，BNP)，作用與人類(lèi)BNP極其相似。Nesiritide中第10和第26個(gè)氨基酸(均為半胱氨酸)之間由一個(gè)二硫鍵聯(lián)接，構(gòu)成了一個(gè)含17個(gè)氨基酸的環(huán)狀結(jié)構(gòu)，所以Nesiritide的穩(wěn)定性比較好，且在生物體內(nèi)擁有較長(zhǎng)的半衰期。研究表明，以人工合成的Nesiritide為主要原料的藥物在心力衰竭，特別是急性心力衰竭的治療中具有明確的療效。
Nesiritide Acetate is a peptide containing 32 amino acids, first obtained from Escherichia coli using recombinant DNA technology as a synthetic human brain natriuretic peptide (BNP), which functions very similarly to human BNP. The 10th and 26th amino acids (both cysteine) in Nesritide are connected by a disulfide bond, forming a cyclic structure containing 17 amino acids. Therefore, Nesritide has good stability and a long half-life in organisms. Research has shown that drugs primarily made from artificially synthesized Nesiritide have clear therapeutic effects in the treatment of heart failure, especially acute heart failure.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
關(guān)鍵字： 奈西立肽;Nesiritide Acetate ;