產(chǎn)品說明

β2-選擇性腎上腺素能激動劑

該產(chǎn)品包含在以下化合物庫中:

質(zhì)量控制

• 純度 = 98.00%

化學(xué)性質(zhì)

CAS號	67346-49-0	?	?
別名	(-)-Formoterol;Arformoterol;Formoterol
分子式	C19H24N2O4	分子量	344.4
溶解性	25℃: DMSO	儲存條件	Store at -20°

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實驗操作

細胞實驗[2]：
細胞系
溶解方法
反應(yīng)時間
應(yīng)用
動物實驗[3]：
動物模型
劑量
注意事項
References:

產(chǎn)品描述

Description:IC50 Value: N/AFormoterol is a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could impart selective beneficial metabolic effects.in vitro: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1[1]. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kδ-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM [3].in vivo: Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor γ coactivator 1α, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1β subcomplex subunit 8) [2]. Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively [4].Clinical trial: N/A