Anti-ICAM1 antibody

Cat. No. ??JC261536 ?
Package?? ?25 μl/100 μl/200 μl
Storage?? ?-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description ? ? ? ? ? ? ? ?? ?Anti-ICAM1 rabbit polyclonal antibody
Applications ? ??? ?ELISA, WB, IHC?
Immunogen ? ? ? ? ? ?? ?Synthetic peptide of human ICAM1
Reactivity ? ? ? ? ? ? ?? ?Human
Content ? ? ? ? ? ? ? ? ?? ?0.4 mg/ml
Host species ? ? ? ? ? ?? ?Rabbit
Ig class ? ? ? ? ? ? ??? ?Immunogen-specific rabbit IgG
Purification ? ? ? ? ? ? ?? ?Antigen affinity purification

Target information
Symbol ? ? ? ? ? ? ?? ?ICAM1
Full name ? ? ? ? ? ? ?? ?intercellular adhesion molecule 1
Synonyms?? ?BB2; CD54; P3.58
Swissprot?? ?P05362

Target Background
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Anti-ICAM1 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and membrane
Positive control: Human lung cancer
Recommended dilution: 50-200?? ?Predicted cell location: Cytoplasm and membrane
Positive control: Human breast cancer
Recommended dilution: 50-200