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Phytochemistry

Phytochemistry

IF: 3.2
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Ten undescribed eremophilane and guaiane sesquiterpenes from Penicillium roqueforti

Published:1 August 2023 DOI: 10.1016/j.phytochem.2023.113722 PMID: 37230212
Shuyuan Mo , Zhangyan Huang , Zi Ye , Jie Yin, Sitian Zhang, Jun Yao, Yaxin Zhang, Zhihong Huang, Hanxiao Zeng, Zhengxi Hu, Jianping Wang, Yonghui Zhang

Abstract

Nine undescribed eremophilane sesquiterpenes, one undescribed guaiane sesquiterpene, along with ten known analogues were isolated and identified from fungus Penicillium roqueforti, which was separated from the root soil of Hypericum beanii N. Robson collected from the Shennongjia Forestry District, Hubei Province. Their structures were elucidated on the basis of various spectroscopic analyses, mainly including NMR and HRESIMS data, 13C NMR calculations with DP4+ probability analyses, ECD calculations, and single-crystal X-ray diffraction experiments. Furthermore, all twenty compounds were evaluated for the in vitro cytotoxic activities against seven human tumor cell lines, and the result suggested that 14-hydroxymethylene-1(10)-ene-epi-guaidiol A exhibited considerable cytotoxic activity against the Farage (IC50?<?10?μM, 48?h), SU-DHL-2, and HL-60?cells. Further mechanism study demonstrated that 14-hydroxymethylene-1(10)-ene-epi-guaidiol A could significantly promote apoptosis by inhibiting tumor cell respiration and decreasing intracellular ROS levels, thereby inducing S-phase blockade in tumor cells.

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