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ChemicalBook >> journal list >> Materials Science & Engineering C-Materials for Biological Applications >>article

Natural nanogels crosslinked with S-benzyl-L-cysteine exhibit potent antibacterial activity

Published:1 October 2023 DOI: 10.1016/j.bioadv.2023.213551 PMID: 37441957
Fang-Yu Chung , Cheng-Rung Huang , Chang-Shi Chen , Yu-Fon Chen

Abstract

Biofilm-forming bacteria E. coli and P. aeruginosa have both exhibited resistance against multiple antibiotics in clinical settings. To find a solution, researchers have turned to antibacterial structurally modified from natural materials that are harmless to the human body. Among these is DNA, a natural polymer composed of deoxyribose that when treated with HCl exposes its aldehyde groups and produces DNA-HCl. Here, we crosslinked these aldehyde groups with the primary amines in S-benzyl-L-cysteine (SBLC) using a Schiff reaction to obtain DNA-HCl-SBLC. We additionally treated alginate acid (AA) with EDAC, obtaining AA-EDAC, and substituting it with SBLC to produce AA-SBLC. We incorporated the above reactions with an emulsification process to produce nanogels (NGs) that were verified to be spherical and possessing benzene rings successfully grafted onto DNA-HCl and AA-EDAC. These natural NGs were proven to be negatively charged through zeta potential analysis and presented low cytotoxicity toward normal cells in cell organoid viability assays. These SBLC-modified polymers provided better inhibition of bacterial growth than those without modification. Moreover, after incubation with SBLC-modified NGs, bacteria expressed intracellular recA or pvdA in a dose-dependent manner, which was consistent with SEM data from damaged bacteria. Out of four tested NGs, DNA-HCl-SBLC NGs suppressed P. aeruginosa-induced sepsis most effectively and extended the lifespan of C. elegans. This study provides an alternative clinical solution to antibiotics-resistant biofilm strains.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
S-Benzyl-L-cysteine 3054-01-1 C10H13NO2S 207 suppliers $11.00-$1833.00

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