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ChemicalBook >> journal list >> Materials Science & Engineering C-Materials for Biological Applications >>article

Biomimetic oxygen-boosted hybrid membrane nanovesicles as the treatment strategy for ischemic stroke with the concept of the neurovascular unit

Published:1 May 2023 DOI: PMID: 36934713
Xintong Liu , Xinrong Geng , Yijie Shi , Jia Liang , Liang Zhao

Abstract

The pathogenesis of ischemic cerebrovascular disease has revealed that ischemic stroke often leads to deprivation of oxygen, blood-brain barrier (BBB) damage and enhanced inflammatory activation, eventually causing severe brain tissue damage. Herein, we prepared hybrid membrane nanovesicles (YC-1@[RBC-PL] NVs) composed of red blood cell (RBC) membrane and platelet (PL) membrane encapsulating hypoxia inducible factor-1α (HIF-1α) inhibitor YC-1 for contributing to the protection of the neurovascular unit (NVU) in ischemic stroke. YC-1@[RBC-PL] NVs targeted the ischemic brain by the thrombus targeting properties of PL membrane and relieved the hypoxia inside ischemic brain in the presence of YC-1 and catalase in YC-1@[RBC-PL] NVs. Finally, YC-1@[RBC-PL] NVs attenuated ischemic injury to NVU by reducing infarct volume, preserving BBB integrity, and blocking activation of astrocyte and microglia in a middle cerebral artery occlusion/reperfusion (MCAO/R) model.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
YC-1 170632-47-0 C19H16N2O2 164 suppliers $18.00-$2841.00
YC-1 170632-47-0 C19H16N2O2 164 suppliers $18.00-$2841.00
YC-1 170632-47-0 C19H16N2O2 164 suppliers $18.00-$2841.00
YC-1 170632-47-0 C19H16N2O2 164 suppliers $18.00-$2841.00

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