一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Current topics in medicinal chemistry >>article
Current topics in medicinal chemistry

Current topics in medicinal chemistry

IF: 2.89
Download PDF

Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature.

Published:1 January 2015 DOI: 10.2174/1568026615666150610142647 PMID: 26059355
Seyed Mohammad Nabavi, Solomon Habtemariam, Maria Daglia, Nady Braidy, Monica Rosa Loizzo, Rosa Tundis, Seyed Fazel Nabavi

Abstract

Extensive evidences has shown the promising effects of Ginkgo biloba consumption on several diseases such as Alzheimer's and Parkinson's diseases, and ischemic stroke, etc. Several studies also have reported its beneficial role on motor activity and cognitive functions. This species contain a unique class of diterpenes, namely Ginkgolide B, which possess several pharmacological activities such as protective effect against cardiovascular disease; the most important causes of death worldwide. The promising effects of Ginkgolide B on stroke, both ischemic and hemorrhagic, are suggested by an overwhelming body of scientific evidences. Many studies have shown that the increase of sirt1 expression, the suppression of nuclear factor kappa-B (NF-kB, the inhibition of the PI3K/Akt pathway and toll-like receptor 4 (TLR4/NF-kB, the up-regulation of heme oxygenase 1, erythropoietin secretion and anti-apoptotic protein expression, the inhibition of pro-apoptotic proteins expression, and the improvement of endothelial NO synthesis are the main molecular mechanisms involved in the protective effect of Ginkgolide B on ischemic stroke. In this review, all the available data on the chemistry, mechanisms of neuroprotection and clinical impacts of Ginkgolide B are critically discussed.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Ginkgolide B 15291-77-7 C20H24O10 407 suppliers $32.00-$4980.00

Similar articles

IF:1.3

Lamivudine treatment for acute severe hepatitis B: report of a case and review of the literature.

Acta gastro-enterologica Belgica A Roussos, S Koilakou,etc Published: 1 January 2008
IF:6.1

Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.

Phytotherapy Research Karin Woelkart, Elisabeth Feizlmayr,etc Published: 1 March 2010
辽阳市| 临洮县| 浮山县| 西乌珠穆沁旗| 商河县| 海伦市| 苍溪县| 读书| 万年县| 新田县| 亚东县| 绥棱县| 南投市| 泾川县| 三明市| 漯河市| 陆河县| 囊谦县| 永和县| 商洛市| 弥渡县| 陆河县| 醴陵市| 汉寿县| 隆化县| 黔西县| 乌鲁木齐县| 安吉县| 高雄县| 平和县| 瑞金市| 呼伦贝尔市| 南川市| 方正县| 石台县| 舒城县| 保山市| 平度市| 大连市| 郧西县| 嘉义县|