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Current topics in medicinal chemistry

Current topics in medicinal chemistry

IF: 2.89
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Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities.

Published:8 August 2024 DOI: 10.2174/0115680266311332240722065652 PMID: 39129163
Bubun Banerjee,?Aditi Sharma,?Arvind Singh,?Manmeet Kaur,?Anu Priya

Abstract

Isatin or 1H-indole-2,3-dione skeleton has been playing a significant role in drug de-sign and development. Isatin itself and many of its derivatives are widely distributed in naturally occurring bioactive compounds. Various synthetic isatin derivatives were found to possess a broad range of significant pharmacological efficacies especially anti-cancer activity against a wide variety of cancer cell lines. Interestingly, on a few occasions, some isatin-derived scaffolds were reported as more potent than the tested reputed drug molecules. As a result, isatin-derived compounds have been gaining significant attention in cancer-based drug developments. In this re-view, we have summarized literature reported during the last two decades related to the synthesis of structurally diverse isatin-derived scaffolds with promising anti-cancer activities.

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